Treatment was changed to dcep regimen, and daratumumab was added for primary refractory myeloma. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The changing paradigm patient case and question a 65yearold violinist is diagnosed with myeloma and receives revlimid, velcade, and dexamethasone rvd followed by highdose melphalan and stem cell transplantation and revlimid maintenance. Plasma cells make antibodies against infectious agents such as viruses and bacteria. The aim of this study was to evaluate the efficacy of dcep. Kumar, md, professor of medicine, mayo clinic cancer center, and panel chair of the nccn guidelines for mm, who described mm. Between 70 80% of patients have evidence of myeloma bone disease at the time of diagnosis and most patients will get myeloma bone disease at some point.
Multiple myeloma is a cancer of the bone marrow plasma cells. Introduction multiple myeloma mm is a mature bcell neoplastic proliferative disease as well as is additionally referred to as plasma cell myeloma. Commonly used regimens include dcep, cvad, and vtd. Multiple myeloma is a rare type of cancer that initially has few or no symptoms. Framework assessments of multiple myeloma the following section describes each value assessment framework or tool and how they were applied to assess drug regimens for multiple myeloma.
These findings were consistent with the patients history of. Pdf dcep is an effective regimen for peripheral blood stem cell. Myeloma bone disease is the most common and often the most debilitating feature of myeloma and bone pain is a very common symptom. Jan 01, 2004 genomic instability, a hallmark of multiple myeloma, is already present at the stage of monoclonal gammopathy of undetermined significance mgus, 1012 but it is not clear whether mgus represents a prerequisite precursor stage for all cases of myeloma. Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should be handled by an experienced healthcare team. Its diagnosed and treated differently from multiple myeloma.
If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. These properties render dcep a useful regimen for the debulking and mobilization phase of highdose programs for multiple myeloma. In greek, the language of most medical terms, myelo refers to the bloodproducing cells in the bone marrow, and oma refers to a tumor or mass. Dcep regimen buys time for multiple myeloma patients. Overall, only 35% of the patients are younger than 65 years at the time of diagnosis, whereas the remaining twothirds are older. Release notes for triton apendpoint web direct connect. This is a unique case of multiple myeloma in a young. Pdf multiple myeloma mm is caused by the neoplastic proliferation of plasma cells. First, myeloma symptoms like back pain and fatigue are common and mostly caused by benign conditions. Apr 12, 2018 the combination of dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is an effective bridge to autologous stem cell transplant asct or novel agents in patients with relapsed refractory multiple myeloma.
Clinical roundtable monograph clinical advances in hematology. Free download myeloma powerpoint presentation slides. Edited and written by a multidisciplinary group of recognized authorities from the mayo clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from. Although multiple myeloma affects the bones, it begins in plasma cells. Myeloma begins when healthy plasma cells in the bone marrow change and grow out of control. How dcep chemotherapy is given and possible side effects. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. A free powerpoint ppt presentation displayed as a flash slide show on id. I have the impression that dcep typically is used as a bridging therapy. A number of 818 mm patients, who had received an upfront hdtabsct between june 1992 and october 20 at the university hospital heidelberg, heidelberg, germany were included in. To download an epub file to your kobo from a windows computer. Bristol myers squibb and bluebird bios broad clinical development program for idecel includes clinical studies karmma2, karmma3, karmma4 in earlier lines of treatment for patients with multiple myeloma, including newly diagnosed multiple myeloma. Multiple myeloma early detection, diagnosis, and staging 1. International myeloma foundation ma myeloma acronyms and abbreviations oun ation allo.
Although myeloma is incurable, this is a very hopeful time for patients. The development of her cutaneous and mucosal plasmacytomas, despite 4 cycles of rvd, was concerning for refractory disease, and the treatment regimen was switched to dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep. Recent trends in multiple myeloma incidence and survival by age, race, and ethnicity in the. Imwg criteria for the diagnosis of myeloma and guidelines for the diagnostic workup of myeloma criteria for a diagnosis of myeloma followed by the examinations, tests, and imaging studies that are recommended by the working group for the diagnosis of myeloma. I dont have any experience with the dcep regimen, but i do have a one question and one observation that may be helpful. Patients had received a mean of three prior treatment lines range, 111. Click on the icon below to download a pdf booklet on myeloma. Dcep dexamethasone, cyclophosphamide, etoposide, and cisplatin has proved to be an effective salvage therapy for refractoryrelapsed mm patients. We wish to warn you that since myeloma manager files are downloaded from an external source, fdm lib bears no responsibility for the safety of such downloads. An effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma. Your doctor will examine you and ask about your symptoms, medical history and overall health. Each cycle of dcep consisted of cyclophosphamide 400 mgm2 daily. Multiple myeloma mm is a malignant plasma cell disorder that accounts for approximately 10 percent of all hematologic malignancies. For a free electronic download of these slides, please direct your browser.
Alternatively, you can download the file locally and open with any standalone pdf reader. Advancing against multiple myeloma center for cancer. Multiple myeloma free download as powerpoint presentation. Introduction multiple myeloma mm is a mature bcell neoplastic proliferative disease as well as is additionally referred to as plasma cell myeloma, myelomatosis, or kahler disease 1. Incidence of adrenal insufficiency in patients with multiple myeloma during high dose chemotherapy and autologous stem cell transplant. Multiple myeloma mm, also known as symptomatic plasma cell myeloma, is a plasma cell malignancy.
Dexamethasone, cyclophosphamide, etoposide and cisplatin dcep for relapsed or refractory multiple myeloma patients. Some early cancers may have signs and symptoms that can be noticed, but that is not always the case. In multiple myeloma, white blood cells known as plasma cells divide uncontrollably in the bone marrow. While vtdpace contains bortezomib and thalidomide which have potent antimyeloma activity. Multiple myeloma early detection, diagnosis, and staging. Multiple myeloma mm is a cancer of postgerminal center plasma. Dcep as a bridge to ongoing therapies for advanced relapsed and.
Pdf the treatment of multiple myeloma mm continues to evolve with the approval of numerous agents over the past decade. Emergency physicians should suspect multiple myeloma based on pathologic fractures, back or bone pain at rest, normocytic anemia, and renal failure in an older patient. Herman liu feb 2010 discussion 1 basics 2 work up 3 treatment discussion 1 basics 2 work up 3 treatment terminology 1. Each cycle of dcep consisted of cyclophosphamide 400 mgm2daily. The predominant change to the nccn guidelines for multiple myeloma mm is the grouping of treatment regimens according to preferred, other, and useful in certain circumstances, according to shaji k. Fiftyfive mm patients received dcep followed by gcsf as part of. Extramedullary multiple myeloma is defined by the presence of plasma cell infiltration outside.
Recently, the introduction of newer agents such as. Sorry to hear that your transplant didnt have that much of an effect on your multiple myeloma. A cancerous or malignant plasma cell is called a myeloma cell. Alternatively, you can download the file locally and open with any standalone pdf. Dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is one of the salvage options, but there has been a lack of data on salvage dcep in patients with previous exposure to novel agents. Bone marrow plasmacytosis as well as production of.
The combination of dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is an effective bridge to autologous stem cell transplant asct or novel agents in patients with relapsed refractory multiple myeloma. The imfs library of more than 100 publications, for patients and caregivers as well. Incidence of adrenal insufficiency in patients with multiple. This causes them to interfere with the production of normal blood cells. Diagnostic and clinical implications ronald walker, bart barlogie, jeffrey haessler, guido tricot, elias anaissie, john d.
Relapsedrefractory, multiple myeloma, dcep, salvage chemotherapy, chemotherapeutic approaches. In greek, the language of most medical terms, myelo refers. Multiple myeloma is a type of blood cancer that affects the bone marrow, the bodys bloodforming system. Multiple myeloma also known as mm, myeloma, plasma cell myeloma, or as kahlers disease after otto kahler is a type of cancer of plasma cells, immune system cells in bone marrow that produce antibodies. Dcep dexamethasone, cyclophosphamide, etoposide, and. Nov 16, 20 multiple myeloma remains incurable despite the use of novel agents. Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should. Dec 06, 2014 ahmad hatem mattour, shatha farhan, nalini janakiraman, edward peres. Multiple myeloma mm is a cancer that occurs in plasma cells, which fall under the category of white blood cells that are in charge of antibody production. These neoplastic plasma cells proliferate and produce monoclonal immunoglobulin in the bone marrow causing skeletal damage, a hallmark of multiple myeloma. Recent trends in multiple myeloma incidence and survival.
Multiple myeloma treatment regimens part 1 of 9 clinical trials. Ppt multiple myeloma powerpoint presentation free to. Use of krdpace as salvage therapy in aggressive, relapsed. Treatment of multiple myeloma blood american society of. The understanding of these pathways is closely linked to their therapeutic implications and is stressed upon in the initial chapters. This helps you give your presentation on myeloma in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. The nccn recommends cancer patient participation in clinical trials as the gold standard for treatment. Little is known, however, about its potential as mobilizing therapy. Jan 01, 2014 read dcep for relapsed or refractory multiple myeloma after therapy with novel agents, annals of hematology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. A myeloma cell develops from a single flawed plasma cell.
Release notes for triton apendpoint web direct connect for windows build 3331 updated 10aug2016 triton apendpoint web now includes 2 endpoint client options. Comparison of value framework assessments for multiple. Overview of multiple myeloma, risk factors, treatment approaches. Multiple myeloma remains incurable despite the use of novel agents. Powerpoint is the worlds most popular presentation software which can let you create professional myeloma powerpoint presentation easily and in no time. Commonly used regimens include dcep, cvad, and vtd pace. Low numbers of these cells may also be found in the bloodstream whenever the immune system is triggered. It is estimated that 21,700 new cases of myeloma will be diagnosed in 2012. The first successful myeloma treatmenta combination of melphalan and. It is synonymous with myeloma and plasma cell myeloma. Multiple myeloma in a young female presenting with. Request pdf dcep for relapsed or refractory multiple myeloma after therapy with novel agents multiple myeloma remains incurable despite the use of novel. Pdf dcep dexamethasone, cyclophosphamide, etoposide, and. Myeloma often damages the bone and is usually called multiple myeloma because.
The changing paradigm patient case and question a 65yearold violinist is diagnosed with myeloma and receives revlimid, velcade, and dexamethasone rvd. It is an incurable disease and the cause of about 20 percent of deaths. Aug 30, 2017 multiple myeloma is a difficult diagnosis to make. Dadacaridou m1, papanicolaou x, maltesas d, megalakaki c, patos p, panteli k, repousis p, mitsoulimentzikof c. Overview of multiple myeloma, risk factors, treatment.
Patients with the disease require multiple treatments to try to slow the division but even with therapy. Dcep for relapsed or refractory multiple myeloma after therapy with. Commonly used regimens include dcep, cvad, and vtdpace. Multiple myeloma early detection, diagnosis, and staging cancer. In this disease, the plasma cells a type of white blood cell become abnormal and multiply rapidly. Pdf current treatment strategies for multiple myeloma. It is characterised by a clonal population of bone marrow plasma cells which secrete a monoclonal. In 2015, an estimated 28,850 new cases of multiple myeloma were. A systematic classification of death causes in multiple. Myeloma is a complex disease to diagnose due to a combination of different factors. Multiple myeloma mm, risk factors, disease progression, therapy, symptomatic, treatment. To download the product you want for free, you should use the link provided below and proceed to the developers website, as this is the only legal source to get myeloma manager. Dadacaridou m1, papanicolaou x, maltesas d, megalakaki c, patos p, panteli k. Myeloma, also called multiple myeloma, is a cancer of the plasma cells.
Dcep for relapsed or refractory multiple myeloma after. Myeloma is a cancer of plasma cells, a type of white blood cell wbc in the bone marrow that is responsible for making immunoglobulins. Dcep is the acronym for a chemotherapy regimen used in the treatment of multiple myeloma d dexamethasone c cyclophosphamide cytoxan e etoposide vepesid p cisplatin platinol chemotherapy is often given as a combination of drugs. The aim of this study was to evaluate the efficacy of dcep in mobilizing pbsc and to define its toxicity. Used iv in combination therapies such as dcep and dvpace. Initial studies 3 years ago showed 55% plasma cells in the bone marrow, hyperdiploidy, igg. This is a comprehensive, stateoftheart guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders.
Multiple myeloma support groups online dailystrength. The direct connect endpoint is a new web endpoint client. Dexamethasone, cyclophosphamide, etoposide and cisplatin dcep. Multiple myeloma is a malignant disorder characterized by the proliferation of plasma cells. I was just last week diagnosed with multiple myeloma after a bone marrow biopsy. Multiple myeloma multiple myeloma is a cancer of the plasma cellsa type of white blood cell. Myeloma is a cancer of the plasma cells in the bone marrow, the spongy tissue inside of bones.
Bristol myers squibb and bluebird bio announce submission. The imwg criteria for a diagnosis of smoldering asymptomatic myeloma include serum mprotein igg or iga. Each year in the united states, about 20,000 people learn they have this disease. Much insight has been gained into the molecular pathways that lead to myeloma and indeed much more remains to be done.